警探史蒂夫·斯隆（Steve Sloan）认为高层经理尼克·奥斯本（Nick Osborn）杀害了他的老板、信托基金所有者拉塞尔·科德（Russell Cord）。他的父亲、资深医院医生马克·斯隆（Mark Sloan）坚信他的长期患者奥斯本是无辜的，并且很快发现科德集团（Cord Group）的另外三名高层员工也有杀害老板的动机。马克·斯隆医生假装成警方的医疗顾问……

一名精神病医生密谋杀害他的妻子，以便能和情妇在一起，但在他实施计划之前，他的妻子却神秘失踪了。

Convinced that his long-time patient Nick Osborn didn't murder his boss, Mark Sloan starts investigating the case himself, supported by a junior doctor and a young female pathologist.

A dead body washes up on the ocean. Steve's investigation leads to a farm with migrant workers. The migrant workers are dying from an unknown ailment and Mark struggles to find the cause.

In Los Rios enroute to Los Angeles, Carol makes an urgent call to her father, Dr. Mark Sloan, pleading for help. Arriving in the small, seemingly pleasant mountain town, Mark investigates but the whole community denies knowing anything about his daughter and her husband. Dr. Sloan, however, soon uncovers enough evidence to make him believe that his daughter and son-in-law may have met a tragic end.

Dr Sloan suspects that his flame of long ago, famous heart surgeon Dr Rachel Walters, has murdered US Senator Cabot on the occasion of a guest operation at the community hospital. After a long investigation, Sloan and fellow detectives Dr Bentley and Dr Parker discover her motive: Years ago, Cabot had caused a hit-and-run accident that put her daughter into coma. But how did Dr Walters manage to pass the deadly bacteria on to the senator in front of TV cameras?

Dr Mark Sloan cannot believe that his former student Dr Drummond, an ambitious cosmetic surgeon, has committed suicide. Assisted by his team of hobby detectives, pathologist Amanda Bentley and junior doctor Jack Parker, Sloan tries to investigate the case. He finds out that Drummond and his senior partner, Dr Stern, had used plastic surgery to create a double of rich banker and benefactor Gantry, who is expected to make a major donation to the community hospital. Does Gantry also plan to have his double assassinated in order to vanish with the money himself?

Steven and fellow LAPD Detectives Halloran and Stang (who are partners) find Councilman Watson ( whom they wanted to question about corruption) passed out at home on tranquilizers Mark prescribed; in the next room is his separated wife Janet's corpse. She has been shot and her blood is all over the house. Police Chief Masters, a political rival for the mayoral campaign, refuses to comment. Mark decides to look into Watson's claim to have been framed, working together with Captain Cynthia Pike; even though it may make Steve look bad, he is happy to collaborate. Amanda hopes to work trough her an 'amicable' divorce from baby CJ's dad by becoming a medical examiner in the coroner's office but she finds nothing; this “negative“ finding is enough for Mark to prove there was a frame, and that Stang had motive and opportunity - he shoots himself; his gun was used for Janet's murder. Now Mark sleuths on; Stang could have been framed himself if Masters is in the plot.

During a SWAT bust, Steve's LAPD friend Douglas Quinten 'Doug' Vogel gets killed by a bullet from his own commander, Max Jupe, who is two years from retirement. City Attorney Andrew Chivers forbids Max any contact with the widow Janine, who quickly accepts the 20% profit-sharing legal services of slick attorney Daniel Brent. Actually. Max and Janine were secret lovers who planned Doug's death. Mark quickly catches on when Max is diagnosed with chickenpox, a recent problem in Janine's daycare center, although the lovers claim not to have met in three months. A 'shooting demonstration' by cocky Max proves that he doesn't need glasses and he is a superb marksman. Janine takes another lover-her lawyer Brent, who is suing Max and the city for $10 million.

Teenager Ashley York murders her sick father Arthur by fixing his Deprosine pills to an overdose. Mark doesn't believe it's suicide, there's no note, absolutely no fingerprints and he set the coffee machine timer for after his death; Jesse concurs his intake of other medicines makes no sense for a suicide. Amanda shows Jesse a postcard: his predecessor Jack Stewart has set up a fancy private practice after his residency in Community General. Then Ashley, who overheard the Sloans, 'finds' a note, but computer-printed, and as Mark soon proves posthumously, murder. Ashley's mother, Dr. Elaine York, intends to keep the purse strings of her $7,000,000 trust-fund till she turns 25. Jesse finds out via a financial friend that Elaine, as a doctor certainly capable of the murderous plan, paid Arthur $2,000,000 at their divorce and kept paying the expensive beach-house, while his entire estate goes to Ashly.